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Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured guinea-pig gastric mucous cells

1. The nitric oxide (NO)-donating nitroxybutyl ester of flurbiprofen (NO-flurbiprofen), shows reduced gastro-intestinal toxicity relative to flurbiprofen. NO may exert either pro- or anti-apoptotic effects, while non-steroidal anti-inflammatory drugs may induce apoptosis. The aim of the present work...

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Detalhes bibliográficos
Main Authors: Johal, Kamaljit, Hanson, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572138/
https://ncbi.nlm.nih.gov/pubmed/10864887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703383
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