Intestinal tolerability of nitroxybutyl-flurbiprofen in rats.

BACKGROUND: Nitric oxide derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) are thought to be much less ulcerogenic than their parent compounds. AIM: To compare the effect and potency of flurbiprofen and nitroxybutyl-flurbiprofen to uncouple mitochondrial oxidative phosphorylation (an ear...

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Main Authors: Somasundaram, S, Rafi, S, Jacob, M, Sigthorsson, G, Mahmud, T, Sherwood, R, Price, A B, Macpherson, A, Scott, D, Wrigglesworth, J M, Bjarnason, I
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1027162/
https://ncbi.nlm.nih.gov/pubmed/9203938
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