Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease

1. We have previously shown that manganese enhances L-dihydroxyphenylanine (L-DOPA) toxicity to PC12 cells in vitro. The supposed mechanism of manganese enhancing effect [an increase in L-DOPA and dopamine (DA) auto-oxidation] was studied using microdialysis in the striatum of freely moving rats. 2....

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Main Authors: Serra, Pier Andrea, Esposito, Giovanni, Enrico, Paolo, Mura, Maria A, Migheli, Rossana, Delogu, M Rosaria, Miele, Maddalena, Desole, Maria S, Grella, Giuseppe, Miele, Egidio
Format: Artigo
Jezik:Inglês
Izdano: 2000
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Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572135/
https://ncbi.nlm.nih.gov/pubmed/10864903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703379
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