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Involvement of the cyclic AMP system in the switch from tolerance into supersensitivity to the antinociceptive effect of the opioid sufentanil
1. We have previously demonstrated that chronic and simultaneous treatment of rats with the μ-opioid receptor agonist sufentanil and the Ca(2+) channel blocker nimodipine, not only prevented tolerance development, but the animals became supersensitive to the antinociceptive effect of the opioid. The...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2000
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1572051/ https://ncbi.nlm.nih.gov/pubmed/10781014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703304 |
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