BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist

1. BIIE0246, a newly synthesized non-peptide neuropeptide Y (NPY) Y(2) receptor antagonist, was able to compete with high affinity (8 to 15 nM) for specific [(125)I]PYY(3–36) binding sites in HEK293 cells transfected with the rat Y(2) receptor cDNA, and in rat brain and human frontal cortex membrane...

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Detalhes bibliográficos
Main Authors: Dumont, Yvan, Cadieux, Alain, Doods, Henri, Pheng, Leng Hong, Abounader, Roger, Hamel, Edith, Jacques, Danielle, Regoli, Domenico, Quirion, Rémi
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571943/
https://ncbi.nlm.nih.gov/pubmed/10725255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703162
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