Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols

1. Certain heterocyclic N-oxides are vasodilators and inhibitors of platelet aggregation. The pharmacological activity of the furoxan derivative condensed with pyridazine di-N-oxide 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide (FPTO) and the corresponding furazan (FPDO) was studied....

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Kots, Alexander Ya, Grafov, Mikhail A, Khropov, Yuri V, Betin, Vasily L, Belushkina, Natalya N, Busygina, Olga G, Yazykova, Marina Yu, Ovchinnikov, Igor V, Kulikov, Alexander S, Makhova, Nina N, Medvedeva, Natalya A, Bulargina, Tamara V, Severina, Irina S
Format: Artigo
Idioma:Inglês
Publicat: 2000
Matèries:
Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571938/
https://ncbi.nlm.nih.gov/pubmed/10725265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703156
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars