Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols

1. Certain heterocyclic N-oxides are vasodilators and inhibitors of platelet aggregation. The pharmacological activity of the furoxan derivative condensed with pyridazine di-N-oxide 4,7-dimethyl-1,2,5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide (FPTO) and the corresponding furazan (FPDO) was studied....

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Detalhes bibliográficos
Main Authors: Kots, Alexander Ya, Grafov, Mikhail A, Khropov, Yuri V, Betin, Vasily L, Belushkina, Natalya N, Busygina, Olga G, Yazykova, Marina Yu, Ovchinnikov, Igor V, Kulikov, Alexander S, Makhova, Nina N, Medvedeva, Natalya A, Bulargina, Tamara V, Severina, Irina S
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571938/
https://ncbi.nlm.nih.gov/pubmed/10725265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703156
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