The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608: direct enhancement of Ca(2+) efficacy and increase of Ca(2+) influx by phosphodiesterase inhibition

1. We examined the effects of the novel hypoglycaemic agent JTT-608 [trans-4-(4-methylcyclohexyl)-4-oxobutyric acid] on insulin secretion using rat pancreatic islets, and analysed the mechanism of its effect. 2. JTT-608 augmented 8.3 mM glucose-induced insulin secretion dose-dependently, and there w...

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Hlavní autoři: Mukai, Eri, Ishida, Hitoshi, Fujimoto, Shimpei, Kajikawa, Mariko, Okamoto, Yoshimasa, Fujita, Jun, Hamamoto, Yoshiyuki, Tsuura, Yoshiyuki, Yamada, Yuichiro, Furukawa, Noboru, Ohta, Takeshi, Seino, Yutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571916/
https://ncbi.nlm.nih.gov/pubmed/10696088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703133
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