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Exposure to glibenclamide increases rat beta cells sensitivity to glucose
1. An increased sensitivity to glucose was observed in islets pre-exposed for 1 h to glibenclamide (0.1 μmol 1(−1)), but not to tolbutamide (100 μmol l(−1)), as indicated by a shift to the left of the dose-response curve (EC(50) at 5.8±0.3 mmol l(−1) glucose vs 10.6±0.8 in control islets; n=11, P<...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2000
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571914/ https://ncbi.nlm.nih.gov/pubmed/10696086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703131 |
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