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The pharmacology of hSK1 Ca(2+)-activated K(+) channels expressed in mammalian cell lines

The pharmacology of hSK1, a small conductance calcium-activated potassium channel, was studied in mammalian cell lines (HEK293 and COS-7). In these cell types, hSK1 forms an apamin-sensitive channel with an IC(50) for apamin of 8 nM in HEK293 cells and 12 nM in COS-7 cells. The currents in HEK293 ce...

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Detalhes bibliográficos
Main Authors: Shah, M, Haylett, D G
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571896/
https://ncbi.nlm.nih.gov/pubmed/10683185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703111
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