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Ser(203) as well as Ser(204) and Ser(207) in fifth transmembrane domain of the human β(2)-adrenoceptor contributes to agonist binding and receptor activation
We examined the contribution of Ser(203) of the human β(2)-adrenoceptor (β(2)-AR) to the interaction with isoprenaline. The affinity of (−)-isoprenaline was reduced by substitution of an alanine for Ser(203), as well as for Ser(204) and Ser(207). An (−)-isoprenaline derivative with only one hydroxyl...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1571654/ https://ncbi.nlm.nih.gov/pubmed/10510435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702813 |
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