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Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats

1. In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused by a continuous intracerebroventricular (i.c.v.) infusion of amyloid β-peptide (Aβ), the major constituent of senile plaques in AD. 2. Neither long-term (3 months) n...

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Detalhes bibliográficos
Main Authors: Yamada, Kiyofumi, Tanaka, Tomoko, Zou, Li-Bo, Senzaki, Kouji, Yano, Kohji, Osada, Takashi, Ana, Olariu, Ren, Xiuhai, Kameyama, Tsutomu, Nabeshima, Toshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571652/
https://ncbi.nlm.nih.gov/pubmed/10510453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702811
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