Saccharomyces cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation

The initiation of DNA replication in Saccharomyces cerevisiae depends upon the destruction of the Clb–Cdc28 inhibitor Sic1. In proliferating cells Cln–Cdc28 complexes phosphorylate Sic1, which stimulates binding of Sic1 to SCF(Cdc4) and triggers its proteosome mediated destruction. During sporulatio...

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Main Authors: Sedgwick, Chantelle, Rawluk, Matthew, Decesare, James, Raithatha, Sheetal, Wohlschlegel, James, Semchuk, Paul, Ellison, Michael, Yates, John, Stuart, David
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570159/
https://ncbi.nlm.nih.gov/pubmed/16776651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060363
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