The RAD6/BRE1 Histone Modification Pathway in Saccharomyces Confers Radiation Resistance Through a RAD51-Dependent Process That Is Independent of RAD18

We examine ionizing radiation (IR) sensitivity and epistasis relationships of several Saccharomyces mutants affecting post-translational modifications of histones H2B and H3. Mutants bre1Δ, lge1Δ, and rtf1Δ, defective in histone H2B lysine 123 ubiquitination, show IR sensitivity equivalent to that o...

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Hauptverfasser: Game, John C., Williamson, Marsha S., Spicakova, Tatiana, Brown, J. Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569736/
https://ncbi.nlm.nih.gov/pubmed/16783014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057794
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