Cumulative Mutations Affecting Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae Result in Synthetic Lethality That Is Suppressed by Alterations in Sphingolipid Profiles

UPC2 and ECM22 belong to a Zn(2)–Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans. Previous reports suggest that double deletion of these genes in S. cerevisiae is lethal depending on the gen...

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Main Authors: Valachovic, Martin, Bareither, Bart M., Bhuiyan, M. Shah Alam, Eckstein, James, Barbuch, Robert, Balderes, Dina, Wilcox, Lisa, Sturley, Stephen L., Dickson, Robert C., Bard, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569731/
https://ncbi.nlm.nih.gov/pubmed/16702413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.053025
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