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Using Substrate-Binding Variants of the cAMP-Dependent Protein Kinase to Identify Novel Targets and a Kinase Domain Important for Substrate Interactions in Saccharomyces cerevisiae

Protein kinases mediate much of the signal transduction in eukaryotic cells and defects in kinase function are associated with a variety of human diseases. To understand and correct these defects, we will need to identify the physiologically relevant substrates of these enzymes. The work presented h...

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Główni autorzy: Deminoff, Stephen J., Howard, Susie C., Hester, Arelis, Warner, Sarah, Herman, Paul K.
Format: Artigo
Język:Inglês
Wydane: Copyright © 2006 by the Genetics Society of America 2006
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Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569720/
https://ncbi.nlm.nih.gov/pubmed/16751660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.059238
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