Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration

Choroidal neovascularization (CNV), the advanced stage of age-related macular degeneration (AMD), accounts for >80% of vision loss in AMD. Carboxyethylpyrrole (CEP) protein modifications, uniquely generated from oxidation of docosahexaenoate-containing lipids, are more abundant in Bruch’s membran...

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Autors principals: Ebrahem, Quteba, Renganathan, Kutralanathan, Sears, Jonathan, Vasanji, Amit, Gu, Xiaorong, Lu, Liang, Salomon, Robert G., Crabb, John W., Anand-Apte, Bela
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569188/
https://ncbi.nlm.nih.gov/pubmed/16938854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601552103
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