Genetic analysis of the K-rev-1 transformation-suppressor gene.

Flat revertants with reduced malignancy in vivo can be isolated from Kirsten sarcoma virus-transformed NIH 3T3 cells (DT line) following transfection with a normal human fibroblast cDNA expression library. We have recovered from one such revertant a 1.8-kb cDNA clone, K-rev-1, that exhibits an activ...

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Main Authors: Kitayama, H, Matsuzaki, T, Sugimoto, Y, Ikawa, Y, Noda, M
Format: Artigo
Sprog:Inglês
Udgivet: 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568041/
https://ncbi.nlm.nih.gov/pubmed/1773804
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