Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

Heparin-binding epidermal growth factor (HB-EGF) and betacellulin (BTC) are activating ligands for EGF receptor (EGFR/ErbB1) and ErbB4. To identify their physiological functions, we disrupted mouse HB-EGF and BTC alleles by homologous recombination. Most HB-EGF(–/–) mice died before weaning, and sur...

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Pubblicato in:	EMBO J
Autori principali:	Jackson, Leslie F., Qiu, Ting Hu, Sunnarborg, Susan W., Chang, Aileen, Zhang, Chunlian, Patterson, Cam, Lee, David C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156761/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12773386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg264
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