Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling
Heparin-binding epidermal growth factor (HB-EGF) and betacellulin (BTC) are activating ligands for EGF receptor (EGFR/ErbB1) and ErbB4. To identify their physiological functions, we disrupted mouse HB-EGF and BTC alleles by homologous recombination. Most HB-EGF(–/–) mice died before weaning, and sur...
Gespeichert in:
| Veröffentlicht in: | EMBO J |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156761/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12773386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg264 |
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