Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.

Dietary administration of the hepatocarcinogen 2-acetylaminofluorene (2-AAF) to rats results in the formation of a major hepatic DNA adduct, N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF). In liver DNA, dG-C8-AF reaches steady-state conditions after approximately 2 weeks of feeding and is removed...

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Bibliografski detalji
Glavni autori: Culp, S J, Poirier, M C, Beland, F A
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567074/
https://ncbi.nlm.nih.gov/pubmed/8319642
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