Nitroreduction and formation of hemoglobin adducts in rats with a human intestinal microflora.

In the covalent binding of nitroarenes to macromolecules, nitroreduction is an important step. The intestinal microflora represents an enormous potential of bacterial nitroreductase activity. As a consequence, the in vivo nitroreduction of orally administered nitroarenes is primarily located in the...

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Библиографические подробности
Главные авторы: Scheepers, P T, Straetemans, M M, Koopman, J P, Bos, R P
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566859/
https://ncbi.nlm.nih.gov/pubmed/7889856
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