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Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca(2+) regulation prevail over changes in insulin content
1. To determine how pretreatment with sulphonylureas alters the β cell function, mouse islets were cultured (18–20 h) without (controls) or with (test) 0.01 μM glibenclamide. Acute responses to glucose were then determined in the absence of glibenclamide. 2. Test islets were insensitive to drugs (su...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1999
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1566176/ https://ncbi.nlm.nih.gov/pubmed/10482920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702731 |
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