Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells

1. Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. It was hypothesized that antisense oligonucleotide down-regulation of TS mRNA would decrease TS levels and enhance the cytotoxicity of inhibitors of TS, including the p...

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Bibliografische gegevens
Hoofdauteurs: Ferguson, Peter J, Collins, Olga, Dean, Nicholas M, DeMoor, Janice, Sha-Li, Chen, Vincent, Mark D, Koropatnick, James
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
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Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566173/
https://ncbi.nlm.nih.gov/pubmed/10482907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702728
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