The antiplatelet activity of PMC, a potent α-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase

1. PMC, a potent α-tocopherol derivative, dose-dependently (5–25 μM) inhibited the ATP-release reaction and platelet aggregation in washed human platelets stimulated by agonists (collagen and ADP). 2. PMC also dose-dependently inhibited the intracellular Ca(2+) mobilization, whereas it did not inhib...

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Detalhes bibliográficos
Main Authors: Sheu, Joen R, Lee, Cheng R, Lin, Chang C, Kan, Ya C, Lin, Chien H, Hung, Wei C, Lee, Yen M, Yen, Mao H
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566113/
https://ncbi.nlm.nih.gov/pubmed/10455267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702637
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