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The effect of site-directed mutagenesis of two transmembrane serine residues on agonist-specific coupling of a cloned human α(2A)-adrenoceptor to adenylyl cyclase
1. The effects of substitution of the Ser(200) and Ser(204) residues with alanine on the signalling properties of the cloned human α(2A)-adrenoceptor, stably expressed in Chinese hamster ovary (CHO) cell lines, have been investigated using noradrenaline and the structural isomers of octopamine. 2. T...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1566090/ https://ncbi.nlm.nih.gov/pubmed/10433494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702614 |
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