Cyclic AMP suppresses interleukin-5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway

1. To delineate the mechanism by which cyclic AMP (cAMP) suppresses interleukin (IL)-5 synthesis, the effects of prostaglandin (PG) E(2), forskolin, dibutyryl (db)-cAMP and the Ca(2+) ionophore, ionomycin on cytokine synthesis, proliferation and CD25 expression of human T cells were investigated. Fu...

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Detalhes bibliográficos
Main Authors: Kaminuma, Osamu, Mori, Akio, Ogawa, Koji, Kikkawa, Hideo, Nakata, Aya, Ikezawa, Katsuo, Okudaira, Hirokazu
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1566030/
https://ncbi.nlm.nih.gov/pubmed/10385254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702558
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