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Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats
1. The objective of this investigation was to characterize quantitatively the influence of the rate of increase in blood concentrations on the pharmacodynamics of midazolam in rats. The pharmacodynamics of midazolam were quantified by an integrated pharmacokinetic-pharmacodynamic modelling approach....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565986/ https://ncbi.nlm.nih.gov/pubmed/10369477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702499 |
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