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Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin-releasing hormone receptor: role of cellular calcium and protein kinase C
1. C335Stop is a constitutively active mutant of the TRH receptor (TRH-R). To investigate the mechanism of the decreased responsiveness of C335Stop TRH-R, we studied cellular Ca(2+) concentrations ([Ca(2+)](i)) in AtT20 cells stably transfected with C335Stop TRH-R cDNA, or Ca(2+)-activated chloride...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565886/ https://ncbi.nlm.nih.gov/pubmed/10204996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702415 |
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