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Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin-releasing hormone receptor: role of cellular calcium and protein kinase C

1. C335Stop is a constitutively active mutant of the TRH receptor (TRH-R). To investigate the mechanism of the decreased responsiveness of C335Stop TRH-R, we studied cellular Ca(2+) concentrations ([Ca(2+)](i)) in AtT20 cells stably transfected with C335Stop TRH-R cDNA, or Ca(2+)-activated chloride...

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Detaylı Bibliyografya
Asıl Yazarlar: Grimberg, Hagit, Zaltsman, Ilona, Lupu-Meiri, Monica, Gershengorn, Marvin C, Oron, Yoram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1999
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565886/
https://ncbi.nlm.nih.gov/pubmed/10204996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702415
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