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Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of I(to1) in cardiac electrogenesis

1. In the present study, two new peptides, phrixotoxins PaTx1 and PaTx2 (29–31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. 2. Phrixotoxins specifically block Kv4.3 and Kv4.2 currents that underlie I(to1), wit...

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Detalhes bibliográficos
Main Authors: Diochot, Sylvie, Drici, Milou-Daniel, Moinier, Danielle, Fink, Michel, Lazdunski, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565788/
https://ncbi.nlm.nih.gov/pubmed/10051143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702283
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