Long term orexigenic effect of a novel melanocortin 4 receptor selective antagonist

1. We designed and synthesized several novel cyclic MSH analogues and tested their affinities for cells expressing the MC1, MC3, MC4 and MC5 receptors. 2. One of the substances HS028 (cyclic [AcCys(11), dichloro-D-phenylalanine(14), Cys(18), Asp-NH(2)(22)]-β-MSH(11–22)) showed high affinity (Ki of 0...

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Detalhes bibliográficos
Main Authors: Skuladottir, Gudrun V, Jonsson, Logi, Skarphedinsson, Jon O, Mutulis, Felikss, Muceniece, Ruta, Raine, Amanda, Mutule, Ilze, Helgason, Johannes, Prusis, Peteris, Wikberg, Jarl E S, Schiöth, Helgi B
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565775/
https://ncbi.nlm.nih.gov/pubmed/10051117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702264
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