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Role of cyclo-oxygenase-2 induction in interleukin-1β induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline

1. Airway smooth muscle (ASM) in human asthma shows reduced relaxation and cyclic AMP generation in response to β-adrenoceptor agonists. IL-β attenuates cyclic AMP generation but the underlying mechanism is unclear. We have reported that IL-1β induces cyclo-oxygenase-2 (COX-2) in human ASM cells and...

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Bibliografische gegevens
Hoofdauteurs: Pang, Linhua, Holland, Elaine, Knox, Alan J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1998
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565701/
https://ncbi.nlm.nih.gov/pubmed/9863663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702193
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