Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

1. The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies. 2. In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2±1.8 ml min(−1) in controls (...

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Bibliografiska uppgifter
Huvudupphovsmän: Batty, Kevin T, Ilett, Kenneth F, Edwards, Geoffrey, Powell, Shane M, Maggs, James L, Park, B Kevin, Davis, Timothy M E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1998
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Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565587/
https://ncbi.nlm.nih.gov/pubmed/9776356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702023
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