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Potent inhibition of both the acute and delayed emetic responses to cisplatin in piglets treated with GR205171, a novel highly selective tachykinin NK(1) receptor antagonist
1. The effects of GR205171, a selective tachykinin NK(1) receptor antagonist, were investigated on both the acute and delayed phases of cisplatin-induced nausea-like behaviour and vomiting in the conscious piglet. 2. Animals receiving cisplatin (5.5 mg kg(−1), i.v.) were observed for 60 h. Fifteen m...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1998
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565571/ https://ncbi.nlm.nih.gov/pubmed/9756379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702019 |
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