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Potent inhibition of both the acute and delayed emetic responses to cisplatin in piglets treated with GR205171, a novel highly selective tachykinin NK(1) receptor antagonist

1. The effects of GR205171, a selective tachykinin NK(1) receptor antagonist, were investigated on both the acute and delayed phases of cisplatin-induced nausea-like behaviour and vomiting in the conscious piglet. 2. Animals receiving cisplatin (5.5 mg kg(−1), i.v.) were observed for 60 h. Fifteen m...

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Dettagli Bibliografici
Autori principali: Grélot, Laurent, Dapzol, Julien, Estève, Eric, Frugière, Alain, Bianchi, Armand L, Sheldrick, Robert L G, Gardner, Christopher J, Ward, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565571/
https://ncbi.nlm.nih.gov/pubmed/9756379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702019
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