Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice

1. Excitotoxic and apoptotic mechanisms have been implicated in the pathophysiology of cerebral ischaemia. Both MK-801, an NMDA receptor antagonist, or peptide inhibitors of the caspase family (z-VAD.FMK and z-DEVD.FMK), protect mouse brain from ischaemic cell damage. In this study, we examined whet...

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Bibliographic Details
Main Authors: Ma, Jianya, Endres, Matthias, Moskowitz, Michael A
Format: Artigo
Language:Inglês
Published: 1998
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565432/
https://ncbi.nlm.nih.gov/pubmed/9690868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701871
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