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Modulation of transcription factor NF-κB by enantiomers of the nonsteroidal drug ibuprofen
1. The nonsteroidal drug ibuprofen exists as an R(−)- and S(+)-enantiomer. Only the S(+)-enantiomer is an effective cyclo-oxygenase inhibitor, while the R(−)-enantiomer is inactive in this respect. Thus the molecular mechanism by which R(−)-ibuprofen exerts its anti-inflammatory and antinociceptive...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1998
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565210/ https://ncbi.nlm.nih.gov/pubmed/9517383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701652 |
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