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Okadaic acid-induced decrease in the magnitude and efficacy of the Ca(2+) signal in pancreatic β cells and inhibition of insulin secretion

1. Phosphorylation by kinases and dephosphorylation by phosphatases markedly affect the biological activity of proteins involved in stimulus-response coupling. In this study, we have characterized the effects of okadaic acid, an inhibitor of protein phosphatases 1 and 2A, on insulin secretion. Mouse...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Sato, Yoshihiko, Mariot, Pascal, Detimary, Philippe, Gilon, Patrick, Henquin, Jean-Claude
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 1998
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1565136/
https://ncbi.nlm.nih.gov/pubmed/9484859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701578
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