Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A(1)-receptor agonist N(6)-(p-sulphophenyl)adenosine in rats

1. The purpose of this study was to develop and validate an integrated pharmacokinetic-pharmacodynamic model for the anti-lipolytic effects of the adenosine A(1)-receptor agonist N(6)-(p-sulphophenyl)adenosine (SPA). Tissue selectivity of SPA was investigated by quantification of haemodynamic and an...

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Bibliografiske detaljer
Main Authors: van Schaick, E A, de Greef, H J M M, Langemeijer, M W E, Sheehan, M J, IJzerman, A P, Danhof, M
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564970/
https://ncbi.nlm.nih.gov/pubmed/9351510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701412
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