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Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs

1. Several unrelated drugs have pro-arrhythmic activity associated with an ability to prolong the QT interval of the ECG. The aim of this work was to examine the effects of the antimalarial drug halofantrine in vivo and in vitro. 2. In anaesthetized guinea-pigs consecutive bolus doses of halofantrin...

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Main Authors: Batey, Andrew J, Lightbown, Ian D, Lambert, James P, Edwards, Geoffrey, Coker, Susan J
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564961/
https://ncbi.nlm.nih.gov/pubmed/9351516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701402
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