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Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity
1. KAR-2 (3′'-(β-chloroethyl)-2′',4′'-dioxo-3,5′'-spiro-oxazolidino-4-deacetoxy-vinblastine), is a bis-indol derivative; catharantine is coupled with the vindoline moiety which contains a substituted oxazolidino group. Our binding studies showed that KAR-2 exhibited high affinity...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564756/ https://ncbi.nlm.nih.gov/pubmed/9222552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0701189 |
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