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Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

1. We studied the effects of 3-(5′-hydroxymethyl-2′furyl)-1-benzyl indazole (YC-1) on the activity of purified soluble guanylyl cyclase (sGC), the formation of guanosine-3′ : 5′ cyclic monophosphate (cyclic GMP) in vascular smooth muscle cells (VSMC), and on the tone of rabbit isolated aortic rings...

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Detalhes bibliográficos
Main Authors: Mülsch, Alexander, Bauersachs, Johann, Schäfer, Andreas, Stasch, Johannes-Peter, Kast, Raimund, Busse, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564520/
https://ncbi.nlm.nih.gov/pubmed/9051308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0700982
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