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Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (−)-N-(trans-4-isopropylcyclohexane-carbonyl)-D-phenylalanine (A-4166)

1. (−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166), a novel oral hypoglycaemic agent is a non-sulphonylurea insulin secretagogue. 2. We investigated the insulin-releasing action and hypoglycaemic effect of A-4166 compared to sulphonylureas in vitro and in vivo. 3. A-4166 stimul...

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Sonraí Bibleagrafaíochta
Main Authors: Ikenoue, Takao, Akiyoshi, Megumi, Fujitani, Shoji, Okazaki, Kyoko, Kondo, Nobuo, Maki, Toshio
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1996
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564350/
https://ncbi.nlm.nih.gov/pubmed/9117089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0700875
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