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Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics
The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select and optimize a specific conformation. However, testing this idea has been difficult because of the c...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1564241/ https://ncbi.nlm.nih.gov/pubmed/16954202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603282103 |
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