New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15

The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle. The crystal structure of mouse hepatitis virus strain A59 (MHV-A59) nsp15 is reported at 2.15...

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Detalhes bibliográficos
Main Authors: Xu, Xiaoling, Zhai, Yujia, Sun, Fei, Lou, Zhiyong, Su, Dan, Xu, Yuanyuan, Zhang, Rongguang, Joachimiak, Andrzej, Zhang, Xuejun C., Bartlam, Mark, Rao, Zihe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563835/
https://ncbi.nlm.nih.gov/pubmed/16873248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00525-06
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