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Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression

Nuclear domains called ND10 or PML nuclear bodies contain interferon (IFN)-upregulated proteins like PML and Sp100. Paradoxically, herpes simplex virus 1 (HSV-1) begins its transcriptional cascade at aggregates of ND10-associated proteins, which in turn are destroyed by the HSV-1 immediate-early pro...

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Hlavní autoři: Negorev, Dmitri G., Vladimirova, Olga V., Ivanov, Alexey, Rauscher, Frank, Maul, Gerd G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563809/
https://ncbi.nlm.nih.gov/pubmed/16873258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02164-05
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