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Isolation of an Active Lv1 Gene from Cattle Indicates that Tripartite Motif Protein-Mediated Innate Immunity to Retroviral Infection Is Widespread among Mammals

Lv1/TRIM5α (tripartite motif 5α) has recently emerged as an important factor influencing species-specific permissivity to retroviral infection in a range of primates, including humans. Old World monkey TRIM5α blocks human immunodeficiency virus type 1 (HIV-1) infectivity, and the human and New World...

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Main Authors: Ylinen, Laura M. J., Keckesova, Zuzana, Webb, Benjamin L. J., Gifford, Robert J. M., Smith, Timothy P. L., Towers, Greg J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563707/
https://ncbi.nlm.nih.gov/pubmed/16840314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00516-06
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