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Serial Passage through Human Glioma Xenografts Selects for a Δγ(1)34.5 Herpes Simplex Virus Type 1 Mutant That Exhibits Decreased Neurotoxicity and Prolongs Survival of Mice with Experimental Brain Tumors
Previous studies have described in vitro serial passage of a Δγ(1)34.5 herpes simplex virus type 1 (HSV-1) strain in SK-N-SH neuroblastoma cells and selection of mutants that have acquired the ability to infect and replicate in this previously nonpermissive cell line. Here we describe the selection...
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Glavni autori: | , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
American Society for Microbiology
2006
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563698/ https://ncbi.nlm.nih.gov/pubmed/16840311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00725-06 |
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