Serial Passage through Human Glioma Xenografts Selects for a Δγ(1)34.5 Herpes Simplex Virus Type 1 Mutant That Exhibits Decreased Neurotoxicity and Prolongs Survival of Mice with Experimental Brain Tumors

Previous studies have described in vitro serial passage of a Δγ(1)34.5 herpes simplex virus type 1 (HSV-1) strain in SK-N-SH neuroblastoma cells and selection of mutants that have acquired the ability to infect and replicate in this previously nonpermissive cell line. Here we describe the selection...

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Detalhes bibliográficos
Main Authors: Shah, Amish C., Price, Kathleen H., Parker, Jacqueline N., Samuel, Sharon L., Meleth, Sreelatha, Cassady, Kevin A., Yancey Gillespie, G., Whitley, Richard J., Markert, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563698/
https://ncbi.nlm.nih.gov/pubmed/16840311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00725-06
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