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Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases
The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inh...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563560/ https://ncbi.nlm.nih.gov/pubmed/16940130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00500-06 |
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