Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss

Targeted disruption of the histidine decarboxylase gene (HDC(−/−)), the only histamine-synthesizing enzyme, led to a histamine-deficient mice characterized by undetectable tissue histamine levels, impaired gastric acid secretion, impaired passive cutaneous anaphylaxis, and decreased mast cell degran...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Fitzpatrick, L. A., Buzas, E., Gagne, T. J., Nagy, A., Horvath, C., Ferencz, V., Mester, A., Kari, B., Ruan, M., Falus, A., Barsony, J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12716972/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0934373100
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