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Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very low concentrations represses glucocorticoid receptor (GR) transactivation in a transient transfection system and the activity of an endogenous GR-regulated gene in both a cellular system and an animal model. This repression...

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Autors principals: Webster, Jeanette I., Tonelli, Leonardo H., Moayeri, Mahtab, Simons, S. Stoney, Leppla, Stephen H., Sternberg, Esther M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC156265/
https://ncbi.nlm.nih.gov/pubmed/12724519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1036973100
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